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Overview         (For age - group : Above 16 )

Fully animated ‘Virus - Uncoating ’ covers the virus uncoating process and description of various methods of uncoating used by enveloped and non-enveloped viruses.

Product - Animation
  Size/Duration Subscribe Preview / Trailer
Size (KB) 7168 US$    3.00 Rs.237.00
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Subscription Days = 30 Watch a preview (opens in separate window)
Duration (hr:min:sec) 0:26:0
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This animation has audio.This animation contains sound
Category : Virus Replication
Type : Animation with sound
Animation Type : Advanced

Total animation length
: 26 minutes

The animation covers :

  • Uncoating Process
  • Some examples of uncoating
    • Pore formation: Picornavirus
    • Plasma membrane fusion:
    • Direct uncoating: paramyxoviridae
    • Partial uncoating: Hiv
    • Endosomal fusion: influenza virus
    • Endosomal lysis: adenovirus

    Watch combined preview Watch Preview Animation
    Virus attachment Virus Penetration Virus uncoating Virus synthesis
    Virus Assembly Virus Release Virus Replication
    Watch various movie clips related to Virus Replication. These are 1) Virus Attachment 2) Virus Penetration 3) Virus Uncoating 4) Virus synthesis 5) Virus Assembly Maturation 6) Virus Release 7) Virus Complete Reproductive cycle (replication). Click on the above thumbnails to go to the movie.
    uncoating examples
    Various types of uncoating by enveloped and non-enveloped viruses
    uncoating uncoating endosomal
    Penetration and endosomal uncoating
    uncoating adenovirus
    uncoating influenza
    Uncoating of adenovirus and influenza virus.
    uncoating hiv
    uncoating paramyxoviridae
    Uncoating of HIV virus and paramyxoviridae virus.
    Details of the animation/ movie /software

    The animation starts by brief explanation of the virus replication cycle. It is covered under three main headings 1) Initiation of infection 2) Replication and the expression of the virus genome 3) Release of the mature virions from the infected cells.

    There are eight stages of virus replication these are 1) Attachment 2) Penetration 3) Uncoating 4) Gene expression 5) Genome Replication 6) Assembly 7) Maturation 8) Release

    Uncoating : Uncoating occurs simultaneously with or rapidly after penetration. Hence, this stage is difficult to be studied and remains a relatively poorly understood stage of the replication cycle.

    Uncoating in general refers to the events that expose the viral genome to the host cellular machinery and sets the stage for the viral genome to express its functions required for the replication.

    This stage occurs simultaneously with or rapidly after penetration. In order to express the viral genome to the cell organelles, it is necessary that the virion coat be removed partially or completely. Therefore, once virions are in the cytoplasm, they are generally uncoated to some extent by a variety of processes, including simple dissociation and/or enzyme-mediated partial degradation of the particles, to release the viral genome as a naked nucleic acid or as a nucleoprotein complex.

    The steps involved in the process of disintegration of the protein coat or capsid to release its genome into the cell is called as uncoating. Uncoating may be achieved by the complete or partial removal of the capsid.

    The animation covers:

    • Uncoating Process
    • Some examples of uncoating
      • Pore formation: Picornavirus
      • Plasma membrane fusion:
      • Direct uncoating: paramyxoviridae
      • Partial uncoating: Hiv
      • Endosomal fusion: influenza virus
      • Endosomal lysis: adenovirus

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